Magnolia bark extract is an ancient herbal remedy from Ancient Chinese medicine. Retrieved December 18, 2020, from https://pubmed.ncbi.nlm.nih.gov/18426577/, Talbott, S. M., Talbott, J. Huang, Z. Among most well-known and well-studied of these compounds are honokiol and magnolol. Magnolia officinalis is an herb commonly used in traditional medicine.The bark contains active compounds, honokiol and magnolol that may reduce inflammation, anxiety, or … However, the clinical use of HNK in the treatment of insomnia is restricted by its extremely low oral bioavailability. ... For general health, sleep, stress: Typical magnolia … Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. Honokiol is a natural compound derived from the Magnolia plant that may act as an antioxidant, anti-inflammatory, promote relaxation and healthy sleep, and increase cognitive function. And talk to your doctor before starting to take honokiol to learn about how it may interact with medication and supplements you’re already taking. of the broad spectrum of critical benefits, pure honokiol has become a trusted Neuro-modulating effects of honokiol: A review. powerful natural natural solutions for long-term health and vitality. Honokiol helps raise GABA levels in the brain. The GABAA receptor is fast-acting and results in sedation and reduced stress. Phase 3. Relaxation effects were noted with magnolol in isolation and seems to promote healthy sleep patterns when taken orally. study: Honokiol Improves Insulin Resistance, Hepatic Steatosis, and * How do you take it? Join our mailing list to receive the latest news and updates from Dr. Isaac Eliaz. Retrieved from https://pubmed.ncbi.nlm.nih.gov/27738491/, Talarek, S., Listos, J., Barreca, D., Tellone, E., Sureda, A., Nabavi, S. F., . Most literature sources are from Japanese and Chinese foreign-language publications, clinical studies are on the efficacy of magnolia bark extract (MBE) are limited. The effects of the blend in these two studies suggest that it could provide a natural approach to improving the effects of chronic stress. Human research on the effects on magnolia officinalis on sleep duration and quality are not available as of yet, although current studies seem to support its beneficial effects on stress and anxiety. Therefore, magnolia may also help combat the effects of excessive stress. It is a natural extract from Magnolia bark, used for centuries in traditional medicine in China, Korea, and Japan, due to its perfect combination of bioavailability and ability to support the body through a wide range of mechanisms, often reflected in the scientific research performed on Honokiol, during the past decades (1). (please select at least one option), Live-Fermented Botanical Pre + Probiotic Elixir, Cardiovascular and Circulatory Health Research, Boost Your Immune System’s IQ—with Probiotics, Lion’s Mane Mushrooms: Benefits and Side Effects, Challenge Yourself With This 21 Day Yoga Challenge, What falling in love does to your heart and brain, A Clear Path to Address Cardiovascular Disease—with Modified Citrus Pectin, Fights cancer through Valerian is an herb that has been used for centuries to treat problems like insomnia, … Research shows that both compounds have numerous therapeutic properties and may have the potential for medicinal use. Magnolia bark works as an anxiolytic, helping to lower anxiety and depression and reduce stress. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29925102/, Lee, Y., Lee, Y., Lee, C., Jung, J., Han, S., & Hong, J. study: Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and study: Antidepressant-Like Effect and Mechanism of Action of Honokiol, 2019 Therefore, magnolia bark could be … 2016 Honokiol Research Review. (please select at least one option), Live-Fermented Botanical Pre + Probiotic Elixir, Cardiovascular and Circulatory Health Research, Boost Your Immune System’s IQ—with Probiotics, Lion’s Mane Mushrooms: Benefits and Side Effects, Challenge Yourself With This 21 Day Yoga Challenge, What falling in love does to your heart and brain, A Clear Path to Address Cardiovascular Disease—with Modified Citrus Pectin. Antioxidant activity: As an antioxidant, pure honokiol is 1,000 times more potent than Vitamin E in scavenging free radicals and addressing oxidative stress. Since using Pure Sleep I am averaging 6 hours a night and sleep 2 - 3 hours at a time. In addition to its direct anticancer actions, honokiol is also shown to offer other valuable anti-inflammatory and anti-oxidative effects that relate to its mechanisms against cancer. As a dietary supplement for positive mood and relaxation, take 1 capsule, 1-2 times daily, preferably with food. You can take honokiol as a supplement in pill form. Honokiol offers powerful free radical scavenging benefits against reactive oxygen species.20,21 Its inhibition of reactive oxygen was actually shown to be 1,000 times that of α-tocopherol (vitamin E).22 (Interestingly, honokiol is also a selective pro-oxidant, generating reactive oxygen against certain cancer cells. Retrieved from https://pubmed.ncbi.nlm.nih.gov/21277893/, Hussain, T., Tan, B., Yin, Y., Blachier, F., Tossou, M. C., & Rahu, N. (2016, September 22). Abstract ↑ Fong WF, Tse AK, Poon KH, Wang C. Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1,25-dihydroxyvitamin D3 and retinoic acid. Description Application of Honokiol * As the medicine of anti-inflammatory, antibacterial, antioxidant and anti-tumor drug, it is widely used in the fields of medicine and health products; * As a strong antioxidant, it is widely used in cosmetics industry-Magnolol is a powerful antioxidant in cardiovascular diseases. study: Honokiol Attenuates Memory Impairments, Oxidative Stress, Honokiol. It helps slow down your racing mind that makes you feel anxious and stressed at night. ally in integrative medicine, alongside clinically researched Modified Citrus Because Pain and Inflammation. 2019 Review: Neuroprotective effects of honokiol: from chemistry to medicine. The bark of Magnolia oficinalis has been used in traditional Chinese medicine for centuries to address anxiety and nervous tension and to promote sleep.Some researchers believe that these effects are due to honokiol, a natural compound in the bark. It supports the treatment and prevention of numerous health conditions, targeting a diverse range of pathways with potent bioactivity. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: A pilot, double-blind, placebo-controlled clinical trial. 2018 Honokiol (HNK) is a small-molecule lignin extracted from Magnolia Officinalis, demonstrating high potency in promoting nonrapid eye movement (NREM) sleep by modulating the benzodiazepine site of the GABA A receptor. HonoPure is the only Honokiol on the market with this level of purity; other products contain 50% or less* GABA SUPPLEMENT FOR ANXIETY & STRESS RELIEF: HonoPure promotes gentle relaxation and a sense of calm, safely and effectively. However, as an extract of magnolia bark, it had a role in the results of the studies. Adding magnolia extract to a daily routine may help promote healthy skin, reduce inflammation, generate better sleep and work as an antioxidant. Magnolia bark is a natural remedy sourced from the magnolia tree (Magnolia officinalis) that has been used for centuries in traditional Chinese medicine (TCM).It contains a compound called honokiol that mimics the function of estrogen in the body. The sleep-promoting and anxiolytic effects of honokiol suggest a potential additional role for this neolignan in the anesthetic arena. multiple mechanisms, GABA enhancer: promotes Retrieved from https://pubmed.ncbi.nlm.nih.gov/22537192/, Eliaz, I. 2005 Jul 15;106(2):690-7. When Honokiol was not the only ingredient used in the blend in these studies. In the brain, honokiol enhances the activity of GABA, a brain messenger that helps reduce anxiety and promote relaxation, positive mood and restful sleep. A., & Pugh, M. (2013, August 7). 2018 It has been found to promote the GABAA receptor, allowing the neurotransmitter to better bind to their active sites. Modern science is now exposing the health benefits of magnolia bark supplements. The neolignans found in Magnolia Bark extract (Honokiol and Magnolol) have been found to interact with GABAA receptors in both in vitro and in vivo studies. In addition, GABAA agonists will augment the effects. The polyphenols in magnolia bark — honokiol and magnolol — have been found to help induce and improve sleep. Magnolia is a plant. Research continues to show Retrieved from https://pubmed.ncbi.nlm.nih.gov/23924268, Qu, W., Yue, X., Sun, Y., Fan, K., Chen, C., Hou, Y., . The Best Herbs for Sleep: Honokiol is a polyphenol found in magnolia bark, leaves and seed cones. (8) Improved Sleep with Honokiol Each sleep period was one hour or less with one hour or more between sleep periods. I … How would you like to hear from us? Magnolia bark can also act as a sedative, directly helping to facilitate sleep. Activating Mitochondrial SIRT3. 2017 Documentation on the materials and extracts for several studies is also limited. What is Honokiol. https://www.sciencedirect.com/topics/medicine-and-dentistry/honokiol. Pectin and other advanced therapies earning their place as some of the most Research also shows pure honokiol blocks the production of neuro-toxins, and promotes the growth and development of healthy … Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with glucose intolerance, insulin resistance and type 2 diabetes mellitus (T2DM). Nabavi, S. M. (2017, August 17). (Of course, it’s anti-stress capabilities also help sleep, indirectly.) Epub 2005 Mar 31. The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Currently, there aren’t any official recommendations for how much honokiol you should take each day. Two chemicals found in magnolia bark are honokiol and magnolol, which both have strong antioxidant activity. Because of honokiol’s immunomodulatory effects, it is reasonable to assume that honokiol could be effective in … (2013, July). Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Pure honokiol is a powerful way to help relieve stress and anxiety, and support deep, restful sleep. Pure honokiol is one of these unique compounds. Lemon balm is an herb that is part of the mint family. How would you like to hear from us? When tested among mice with induced sleep disorders, research shows that it can accelerate the initiation of NREM (non-rapid eye movement) sleep. relaxation and sense of calm, Protects neurological and Among the most well-known and well-studied of these compounds are honokiol and magnolol. Valerian root. Magnolia bark also appears to have potent antibacterial and anti-inflammatory effects. ol” with emphasis on the o in the middle syllable. (2012, October 16). Honokiol and magnolol are the active components in magnolia extract. Honokiol (HNK) is a small-molecule lignin extracted from Magnolia Officinalis, demonstrating high potency in promoting nonrapid eye movement (NREM) sleep by modulating the benzodiazepine site of the GABAA receptor. Neuroinflammation in Vascular Dementia, 2019 Honokiol inhibits hepatitis C virus (HCV) infection. Join our mailing list to receive the latest news and updates from Dr. Isaac Eliaz. The ability of ho… People use the bark and flower buds to make medicine. . (2011, January 26). that the important benefits of honokiol are achieved with a purified extract, Science Direct. Retrieved from https://pubmed.ncbi.nlm.nih.gov/28817221/, Woodbury, A., Yu, S., Wei, L., & García, P. (2013, September 11). Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice. Honokiol (Magnolia Bark) is a compound extracted from the Chinese Magnolia Tree (Magnolia Officinalis).It has been used as an herbal remedy for anxiety in China and Japan at low daily doses in tea for 2000 years. Because of its broad-spectrum of benefits and excellent safety profile, pure honokiol has become an essential strategy for protecting and enhancing numerous key areas of health. it comes to honokiol’s efficacy, purity matters. . Progression of Cancers of Different Organs. study: Honokiol Alleviates Cognitive Deficits of Alzheimer’s Disease by Retrieved from https://pubmed.ncbi.nlm.nih.gov/24062717/, Kalman, D. S., Feldman, S., Feldman, R., Schwartz, H. I., Krieger, D. R., & Garrison, R. (2008, April 21). Magnolol and honokiol have been shown to reduce anxiety in various animals 5; Human Research. Neuroprotective effects of honokiol: From chemistry to medicine. Blood. View additional Honokiol research abstracts in our Research Library: DrEliaz.org is a free online health education resource based on Dr. Isaac Eliaz’s principles of patient-driven integrative medicine.